منابع مشابه
Class-Specific Features of Neuronal Wiring
Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstructions of pairs consisting of pyramidal cells (PCs) and GABAergic interneuron...
متن کاملCorrelation analysis of neuronal morphology reveals specificity of wiring mechanisms
Study of developmental wiring mechanisms in complex neuropil requires quantitative characterization of specificity in neuronal connectivity. To this end we propose a new method that detects short-range (few microns) correlations between axonal and dendritic branches in 3D reconstructions of neuronal pairs. This method is based on counting how often axonal branches are present in the vicinity (c...
متن کاملWiring the brain: the biology of neuronal guidance.
The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic ...
متن کاملMechanisms and molecules of neuronal wiring: a primer.
The complex patterns of neuronal wiring in the adult nervous system depend on a series of guidance events during neural development that establish a framework on which functional circuits can be built. In this subject collection, the cellular and molecular mechanisms that underlie neuronal guidance are considered from several perspectives, ranging from how cytoskeletal dynamics within extending...
متن کاملThe impact of axon wiring costs on small neuronal networks
Recent papers by D. Chklovskii and E.M. Izhikevich suggest that wiring costs may play a significant role in the physical layout and function of neuronal structures. About eighty years ago, in his paper on the relationship between diameter and branching angles in trees, C.D. Murray proposed the volume as the cost function which dictates growth. O. Shefi et al. grafted this idea into neuroscience...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aax3221